The article shows evolution of the human-machine interface ergonomic systems in the direction of improvement of integration with human, who connects the controlled technical environments. The author presents a classification of the interfaces and the interface environments depending on the degree of the user's integration with the operating environment. The author describes the following types of the integrative interfaces based on the level of the physical interaction of the mechanical controls intended to complete integration of an actor (actors) in the organized working environment: mechanical, with an immediate visual feedback, the mechanical feedback through an information model, a computer user virtual, neurocomputing, symbiotic, biomorphic, technobiotics hypothetical interfaces embodied in the artificial intelligence environment. The author considers the brain-computer interface, ensuring a direct link with the brain of an operator as one of the promising areas of the inter-system integration, which can be used in the form of a "brain-computer" technology. The author shows fundamental limitations in the technology and methodology for creation of this class of interfaces. The next section of the paper deals with the problems of creation of the hybrid biomorphic neuroadaptive interfaces, including creation of the artificial sensory modalities, which ensure an effective interaction with the operator control system. The author notes the potential of creation of the biomorphic and hybrid interfaces as a result of the joint use of the genetic engineering and technical design as a part of the system of non-classical representations. The key problem in creation of the biomorphic interfaces is the problem of inter-system integration between the classic technical systems and biological systems, which implement the cyclic self-reproduction (autopoiesis), because of the interference in the operational structure of the autopoietic systems, which leads to their destruction. In conclusion, the author points out that the evolution of the human integration with the artificial environment can lead to appearance of an embodied mind in an artificial environment, which goes beyond the human nature, organized like a non-biological media. This issue is currently on the cutting edge of the scientific knowledge and can be interesting as a philosophical problem arising in the extreme boundaries of the inter-system integration of man and technology.